Seong-Wook Lee Selected Research

Catalytic RNA (Ribozymes)

3/2021	Targeted suicide gene therapy for liver cancer based on ribozyme-mediated RNA replacement through post-transcriptional regulation.
2/2020	Small Animal PET Imaging of hTERT RNA-Targeted HSV1-tk Gene Expression with Trans-Splicing Ribozyme.
1/2018	Therapeutic applications of group I intron-based trans-splicing ribozymes.
1/2017	Specific and Efficient Regression of Cancers Harboring KRAS Mutation by Targeted RNA Replacement.
1/2016	Image-aided Suicide Gene Therapy Utilizing Multifunctional hTERT-targeting Adenovirus for Clinical Translation in Hepatocellular Carcinoma.
7/2015	Targeted Regression of Hepatocellular Carcinoma by Cancer-Specific RNA Replacement through MicroRNA Regulation.
1/2015	Targeted anticancer effect through microRNA-181a regulated tumor-specific hTERT replacement.
12/2014	Selective expression of transgene using hypoxia-inducible trans-splicing group I intron ribozyme.
1/2014	Use of tumor-targeting trans-splicing ribozyme for cancer treatment.
3/2012	Selective regression of cancer cells expressing a splicing variant of AIMP2 through targeted RNA replacement by trans-splicing ribozyme.

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Seong-Wook Lee Research Topics

Disease

31	Neoplasms (Cancer) 03/2021 - 08/2004
11	Infections 05/2022 - 11/2003
5	Liver Neoplasms (Liver Cancer) 03/2021 - 09/2006
5	Neoplasm Metastasis (Metastasis) 08/2019 - 10/2006
5	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 08/2004
4	Virus Diseases (Viral Diseases) 05/2022 - 12/2010
3	Colonic Neoplasms (Colon Cancer) 08/2019 - 01/2008
3	Myasthenia Gravis 09/2009 - 01/2002
2	Liver Cirrhosis (Hepatic Cirrhosis) 01/2017 - 06/2014
2	Lung Neoplasms (Lung Cancer) 01/2017 - 03/2012
2	Liver Diseases (Liver Disease) 01/2017 - 06/2014
2	Autoimmune Diseases (Autoimmune Disease) 07/2003 - 01/2002
1	Latent Infection 05/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2018
1	Persistent Infection 01/2017
1	Colorectal Neoplasms (Colorectal Cancer) 01/2017
1	Adenoviridae Infections (Adenovirus Infections) 03/2015
1	Carcinoma (Carcinomatosis) 01/2015
1	Hypoxia (Hypoxemia) 12/2014
1	Respiratory Tract Diseases (Respiratory Tract Disease) 06/2014
1	Fibrosis (Cirrhosis) 06/2014
1	Viremia 02/2012
1	Disease Progression 01/2012
1	Foodborne Diseases 01/2012
1	Peritoneal Neoplasms 01/2008
1	Prostatic Neoplasms (Prostate Cancer) 05/2007
1	Ovarian Neoplasms (Ovarian Cancer) 08/2004
1	Experimental Autoimmune Myasthenia Gravis (Autoimmune Experimental Myasthenia Gravis) 07/2003

Drug/Important Bio-Agent (IBA)

25	Catalytic RNA (Ribozymes)IBA 03/2021 - 08/2004
24	RNA (Ribonucleic Acid)IBA 03/2021 - 08/2004
12	Telomerase (Telomerase Reverse Transcriptase)IBA 03/2021 - 11/2005
10	Thymidine KinaseIBA 02/2020 - 11/2005
9	Proteins (Proteins, Gene)FDA Link 01/2017 - 01/2007
6	Nucleotide AptamersIBA 08/2019 - 07/2003
6	Ganciclovir (Cytovene)FDA LinkGeneric 12/2014 - 11/2005
5	MicroRNAs (MicroRNA)IBA 01/2017 - 02/2012
4	Carcinoembryonic AntigenIBA 08/2019 - 10/2006
4	Messenger RNA (mRNA)IBA 03/2015 - 11/2007
3	ProdrugsIBA 01/2017 - 01/2008
3	Indicators and Reagents (Reagents)IBA 03/2015 - 07/2012
3	AntigensIBA 04/2013 - 01/2002
3	AutoantibodiesIBA 09/2009 - 01/2002
2	Antineoplastic Agents (Antineoplastics)IBA 02/2020 - 03/2012
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 08/2019 - 07/2012
2	Tumor Biomarkers (Tumor Markers)IBA 01/2017 - 01/2012
2	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)IBA 01/2017 - 07/2012
2	LuciferasesIBA 12/2014 - 09/2006
2	LigandsIBA 01/2012 - 06/2010
2	alpha-Fetoproteins (alpha-Fetoprotein)IBA 01/2012 - 05/2007
2	Cholinergic ReceptorsIBA 07/2003 - 01/2002
1	ThymidineIBA 02/2020
1	Pharmaceutical PreparationsIBA 08/2019
1	Caspase 8 (Caspase-8)IBA 08/2019
1	Fluorouracil (Carac)FDA LinkGeneric 08/2019
1	Transforming Growth Factors (Transforming Growth Factor)IBA 03/2019
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	Carrier Proteins (Binding Protein)IBA 01/2017
1	Kupffer cell receptorIBA 01/2017
1	CytokinesIBA 01/2017
1	Heterogeneous Nuclear RNAIBA 01/2017
1	ApolipoproteinsIBA 01/2016
1	Apolipoproteins E (ApoE)IBA 01/2016
1	PhosphoenolpyruvateIBA 01/2016
1	adenovirus associated RNA (VA RNA)IBA 03/2015
1	InterferonsIBA 03/2015
1	ElementsIBA 12/2014
1	Erythropoietin FDA Link 12/2014
1	Phosphoglycerate Kinase (Kinase, Phosphoglycerate)IBA 12/2014
1	Oxygen (Dioxygen)IBA 12/2014
1	danofloxacinIBA 06/2014
1	FluoroquinolonesIBA 06/2014
1	VaccinesIBA 06/2014
1	NucleotidesIBA 01/2014
1	Nucleic AcidsIBA 12/2013
1	Carbon Nanotubes (Carbon Nanotube)IBA 04/2013
1	OligonucleotidesIBA 02/2012
1	Cell Surface ReceptorsIBA 12/2010
1	Peptides (Polypeptides)IBA 12/2010
1	Glycoproteins (Glycoprotein)IBA 12/2010
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 09/2009
1	Biological ProductsIBA 05/2007
1	Amino Acids FDA Link 05/2007
1	Diphtheria ToxinIBA 09/2006
1	Cytotoxins (Cytolysins)IBA 04/2005
1	Subgenomic RNAIBA 08/2004
1	Antiviral Agents (Antivirals)IBA 11/2003

Therapy/Procedure

14	Therapeutics 05/2022 - 11/2003
1	Radiotherapy 12/2014
1	Drug Therapy (Chemotherapy) 12/2014